diff --git a/src/components/Notifications/ToastNotification/ToastNotification.stories.tsx b/src/components/Notifications/ToastNotification/ToastNotification.stories.tsx
index f6b37eea1..f868fd12e 100644
--- a/src/components/Notifications/ToastNotification/ToastNotification.stories.tsx
+++ b/src/components/Notifications/ToastNotification/ToastNotification.stories.tsx
@@ -71,6 +71,13 @@ const PreloadedList = () => {
       "Please try again.",
     );
     toastNotify.caution("You have unsaved changes.");
+    toastNotify.caution(
+      "This cannot be dismissed until the issue is resolved.",
+      undefined,
+      "Action required",
+      undefined,
+      false,
+    );
     toastNotify.toggleListView();
     // eslint-disable-next-line react-hooks/exhaustive-deps
   }, []);
@@ -120,6 +127,19 @@ const PreloadedList = () => {
       <Button onClick={() => toastNotify.caution("You have unsaved changes")}>
         Add Warning
       </Button>
+      <Button
+        onClick={() =>
+          toastNotify.caution(
+            "This cannot be dismissed until the issue is resolved.",
+            undefined,
+            "Action required",
+            undefined,
+            false,
+          )
+        }
+      >
+        Add Non-dismissable Warning
+      </Button>
       <Button onClick={toastNotify.toggleListView}>Toggle List View</Button>
     </div>
   );
diff --git a/src/components/Notifications/ToastNotification/ToastNotification.test.tsx b/src/components/Notifications/ToastNotification/ToastNotification.test.tsx
index 6c7d6408e..759a9b2ed 100644
--- a/src/components/Notifications/ToastNotification/ToastNotification.test.tsx
+++ b/src/components/Notifications/ToastNotification/ToastNotification.test.tsx
@@ -1,6 +1,6 @@
-import React from "react";
-import { render, screen } from "@testing-library/react";
+import { render, screen, within } from "@testing-library/react";
 import userEvent from "@testing-library/user-event";
+import React from "react";
 import ToastNotification from "./ToastNotification";
 import ToastNotificationList from "./ToastNotificationList";
 import { ToastNotificationType } from "./ToastNotificationProvider";
@@ -106,6 +106,19 @@ describe("ToastNotification", () => {
     expect(screen.queryByRole("alert")).not.toBeInTheDocument();
   });
 
+  it("does not render a dismiss button when the notification is not dismissable", () => {
+    render(
+      <ToastNotification
+        notification={{ ...baseNotification, dismissable: false }}
+        show={true}
+        onDismiss={jest.fn()}
+      />,
+    );
+    expect(
+      screen.queryByRole("button", { name: /close/i }),
+    ).not.toBeInTheDocument();
+  });
+
   const notifications: ToastNotificationType[] = [
     {
       id: "1",
@@ -188,6 +201,133 @@ describe("ToastNotification", () => {
     expect(onDismiss).toHaveBeenCalledWith(notifications);
   });
 
+  it("does not render a dismiss button for a non-dismissable notification in the list", () => {
+    const mixedNotifications: ToastNotificationType[] = [
+      ...notifications,
+      {
+        id: "3",
+        type: "caution",
+        message: "Cannot be dismissed.",
+        title: "Warning",
+        dismissable: false,
+      },
+    ];
+
+    render(
+      <ToastNotificationList
+        notifications={mixedNotifications}
+        onDismiss={jest.fn()}
+        groupedCount={{ ...groupedCount, caution: 1 }}
+        show={true}
+      />,
+    );
+
+    const warningItem = screen.getByText("Warning").closest("li");
+    expect(warningItem).not.toBeNull();
+    expect(
+      within(warningItem as HTMLElement).queryByTestId(
+        "notification-close-button",
+      ),
+    ).not.toBeInTheDocument();
+  });
+
+  it("excludes non-dismissable notifications from 'Dismiss all'", async () => {
+    const onDismiss = jest.fn();
+    const mixedNotifications: ToastNotificationType[] = [
+      ...notifications,
+      {
+        id: "3",
+        type: "caution",
+        message: "Cannot be dismissed.",
+        title: "Warning",
+        dismissable: false,
+      },
+    ];
+
+    render(
+      <ToastNotificationList
+        notifications={mixedNotifications}
+        onDismiss={onDismiss}
+        groupedCount={{ ...groupedCount, caution: 1 }}
+        show={true}
+      />,
+    );
+
+    await userEvent.click(screen.getByRole("button", { name: "Dismiss all" }));
+    expect(onDismiss).toHaveBeenCalledWith(notifications);
+    expect(screen.getByText("Cannot be dismissed.")).toBeInTheDocument();
+  });
+
+  it("does not render 'Dismiss all' when no notifications are dismissable", () => {
+    const nonDismissableNotifications: ToastNotificationType[] = [
+      {
+        id: "1",
+        type: "positive",
+        message: "Cannot be dismissed.",
+        title: "Success",
+        dismissable: false,
+      },
+      {
+        id: "2",
+        type: "negative",
+        message: "Also cannot be dismissed.",
+        title: "Failure",
+        dismissable: false,
+      },
+    ];
+
+    render(
+      <ToastNotificationList
+        notifications={nonDismissableNotifications}
+        onDismiss={jest.fn()}
+        groupedCount={groupedCount}
+        show={true}
+      />,
+    );
+
+    expect(
+      screen.queryByRole("button", { name: "Dismiss all" }),
+    ).not.toBeInTheDocument();
+  });
+
+  it("shows a dismiss count that excludes non-dismissable notifications within a filtered severity", async () => {
+    const onDismiss = jest.fn();
+    const mixedCautionNotifications: ToastNotificationType[] = [
+      {
+        id: "1",
+        type: "caution",
+        message: "Can be dismissed.",
+        title: "Warning",
+      },
+      {
+        id: "2",
+        type: "caution",
+        message: "Cannot be dismissed.",
+        title: "Warning",
+        dismissable: false,
+      },
+    ];
+
+    render(
+      <ToastNotificationList
+        notifications={mixedCautionNotifications}
+        onDismiss={onDismiss}
+        groupedCount={{ caution: 2 }}
+        show={true}
+      />,
+    );
+
+    await userEvent.click(
+      screen.getByLabelText("Filter caution notifications"),
+    );
+    expect(
+      screen.getByRole("button", { name: "Dismiss 1" }),
+    ).toBeInTheDocument();
+
+    await userEvent.click(screen.getByRole("button", { name: "Dismiss 1" }));
+    expect(onDismiss).toHaveBeenCalledWith([mixedCautionNotifications[0]]);
+  });
+
   it("calls onHoverStart on mouse enter and onHoverEnd on mouse leave", async () => {
     const onHoverStart = jest.fn();
     const onHoverEnd = jest.fn();
diff --git a/src/components/Notifications/ToastNotification/ToastNotification.tsx b/src/components/Notifications/ToastNotification/ToastNotification.tsx
index d95607dcd..d43a0d3a1 100644
--- a/src/components/Notifications/ToastNotification/ToastNotification.tsx
+++ b/src/components/Notifications/ToastNotification/ToastNotification.tsx
@@ -53,9 +53,13 @@ const ToastNotification: FC<Props> = ({
               title={notification.title ?? DefaultTitles[notification.type]}
               actions={notification.actions}
               severity={notification.type}
-              onDismiss={() => {
-                onDismiss([notification]);
-              }}
+              onDismiss={
+                notification.dismissable === false
+                  ? undefined
+                  : () => {
+                      onDismiss([notification]);
+                    }
+              }
               className="u-no-margin--bottom"
               timestamp={notification.timestamp}
               titleElement="div"
diff --git a/src/components/Notifications/ToastNotification/ToastNotificationList.tsx b/src/components/Notifications/ToastNotification/ToastNotificationList.tsx
index 05745e253..0f591d81b 100644
--- a/src/components/Notifications/ToastNotification/ToastNotificationList.tsx
+++ b/src/components/Notifications/ToastNotification/ToastNotificationList.tsx
@@ -96,17 +96,25 @@ const ToastNotificationList: FC<Props> = ({
     });
   };
 
+  const dismissableNotifications = notifications.filter(
+    (notification) => notification.dismissable !== false,
+  );
+
+  // The notifications that would actually be cleared if the dismiss button
+  // were clicked right now, accounting for any active severity filters.
+  const dismissableNotificationsInView = hasFilters
+    ? dismissableNotifications.filter((notification) =>
+        filters.has(notification.type),
+      )
+    : dismissableNotifications;
+
   const handleGroupedDismiss = () => {
     if (hasFilters) {
-      const notificationsToClear = notifications.filter((notification) =>
-        filters.has(notification.type),
-      );
-      onDismiss(notificationsToClear);
+      onDismiss(dismissableNotificationsInView);
       setFilters(new Set());
       return;
     }
-
-    onDismiss(notifications);
+    onDismiss(dismissableNotifications);
   };
 
   const getSeverityFilters = () => {
@@ -149,18 +157,11 @@ const ToastNotificationList: FC<Props> = ({
 
   const getDismissText = () => {
     if (hasFilters) {
-      const validFilters = Object.keys(groupedCount) as FilterTypes[];
-      let totalCount = 0;
-      for (const filter of validFilters) {
-        if (filters.has(filter)) {
-          totalCount += groupedCount[filter] || 0;
-        }
-      }
-
-      const dismissText = (
-        <span className="dismiss-text">Dismiss {totalCount}</span>
+      return (
+        <span className="dismiss-text">
+          Dismiss {dismissableNotificationsInView.length}
+        </span>
       );
-      return dismissText;
     }
 
     return <span>Dismiss all</span>;
@@ -221,9 +222,13 @@ const ToastNotificationList: FC<Props> = ({
           title={notification.title ?? DefaultTitles[notification.type]}
           actions={notification.actions}
           severity={notification.type}
-          onDismiss={() => {
-            handleDismissNotification(notification);
-          }}
+          onDismiss={
+            notification.dismissable === false
+              ? undefined
+              : () => {
+                  handleDismissNotification(notification);
+                }
+          }
           className={`u-no-margin--bottom individual-notification`}
           timestamp={notification.timestamp}
           titleElement="div"
@@ -256,14 +261,16 @@ const ToastNotificationList: FC<Props> = ({
         {notificationEls}
         <li className="dismiss">
           {getSeverityFilters()}
-          <Button
-            className="u-no-margin--bottom dismiss-button"
-            onClick={handleGroupedDismiss}
-            hasIcon
-          >
-            <Icon name="tidy" />
-            {getDismissText()}
-          </Button>
+          {dismissableNotificationsInView.length > 0 && (
+            <Button
+              className="u-no-margin--bottom dismiss-button"
+              onClick={handleGroupedDismiss}
+              hasIcon
+            >
+              <Icon name="tidy" />
+              {getDismissText()}
+            </Button>
+          )}
         </li>
       </ul>
     </Animate>,
diff --git a/src/components/Notifications/ToastNotification/ToastNotificationProvider.tsx b/src/components/Notifications/ToastNotification/ToastNotificationProvider.tsx
index 21b48ed73..22860da40 100644
--- a/src/components/Notifications/ToastNotification/ToastNotificationProvider.tsx
+++ b/src/components/Notifications/ToastNotification/ToastNotificationProvider.tsx
@@ -21,6 +21,7 @@ const HIDE_NOTIFICATION_DELAY = 5_000;
 export type ToastNotificationType = NotificationType & {
   timestamp?: ReactNode;
   id: string;
+  dismissable?: boolean;
 };
 
 interface Props {
@@ -35,12 +36,14 @@ interface ToastNotificationHelper {
     actions?: NotificationAction[],
     title?: string,
     id?: ToastNotificationType["id"],
+    dismissable?: boolean,
   ) => ToastNotificationType;
   info: (
     message: ReactNode,
     title?: string,
     actions?: NotificationAction[],
     id?: ToastNotificationType["id"],
+    dismissable?: boolean,
   ) => ToastNotificationType;
   failure: (
     title: string,
@@ -48,12 +51,14 @@ interface ToastNotificationHelper {
     message?: ReactNode,
     actions?: NotificationAction[],
     id?: ToastNotificationType["id"],
+    dismissable?: boolean,
   ) => ToastNotificationType;
   caution: (
     message: ReactNode,
     actions?: NotificationAction[],
     title?: string,
     id?: ToastNotificationType["id"],
+    dismissable?: boolean,
   ) => ToastNotificationType;
   clear: (notification?: ToastNotificationType[]) => void;
   toggleListView: () => void;
@@ -234,6 +239,7 @@ const ToastNotificationProvider: FC<PropsWithChildren<Props>> = ({
   const addNotification = (
     notification: NotificationType & { error?: unknown } & {
       id?: ToastNotificationType["id"];
+      dismissable?: boolean;
     },
   ) => {
     const notificationToAdd = {
@@ -242,6 +248,7 @@ const ToastNotificationProvider: FC<PropsWithChildren<Props>> = ({
       id:
         notification.id ??
         Date.now().toString() + (Math.random() + 1).toString(36).substring(7),
+      dismissable: notification.dismissable ?? true,
     };
 
     setNotifications((prev) => {
@@ -299,14 +306,26 @@ const ToastNotificationProvider: FC<PropsWithChildren<Props>> = ({
 
   const helper: ToastNotificationHelper = {
     notifications,
-    failure: (title, error, message, actions, id) =>
-      addNotification({ ...failure(title, error, message, actions), id }),
-    info: (message, title, actions, id) =>
-      addNotification({ ...info(message, title, actions), id }),
-    success: (message, actions, title, id) =>
-      addNotification({ ...success(message, title, actions), id }),
-    caution: (message, actions, title, id) =>
-      addNotification({ ...caution(message, title, actions), id }),
+    failure: (title, error, message, actions, id, dismissable) =>
+      addNotification({
+        ...failure(title, error, message, actions),
+        id,
+        dismissable,
+      }),
+    info: (message, title, actions, id, dismissable) =>
+      addNotification({ ...info(message, title, actions), id, dismissable }),
+    success: (message, actions, title, id, dismissable) =>
+      addNotification({
+        ...success(message, title, actions),
+        id,
+        dismissable,
+      }),
+    caution: (message, actions, title, id, dismissable) =>
+      addNotification({
+        ...caution(message, title, actions),
+        id,
+        dismissable,
+      }),
     clear,
     toggleListView,
     isListView: showList,