From fc6b5a5d43280a6c1cffbfb71fd738e3227fb368 Mon Sep 17 00:00:00 2001 From: mite-bot Date: Wed, 22 Jul 2026 20:22:26 +0200 Subject: [PATCH 1/2] Add submission UUID file --- .../2bc73f10-85f9-11f1-8cab-df74baa3faa7.json | 44 +++++++++++++++++++ 1 file changed, 44 insertions(+) create mode 100644 mite_data/data/2bc73f10-85f9-11f1-8cab-df74baa3faa7.json diff --git a/mite_data/data/2bc73f10-85f9-11f1-8cab-df74baa3faa7.json b/mite_data/data/2bc73f10-85f9-11f1-8cab-df74baa3faa7.json new file mode 100644 index 00000000..de29d207 --- /dev/null +++ b/mite_data/data/2bc73f10-85f9-11f1-8cab-df74baa3faa7.json @@ -0,0 +1,44 @@ +{ + "accession": "MITE9999999", + "status": "pending", + "changelog": [ + { + "version": "1", + "date": "2026-07-22", + "contributors": [ + "0009-0008-8086-5325" + ], + "reviewers": [ + "BBBBBBBBBBBBBBBBBBBBBBBB" + ], + "comment": "New entry." + } + ], + "enzyme": { + "name": "TrpM", + "databaseIds": { + "uniprot": "A0A346RP51", + "genpept": "" + }, + "references": [ + "doi:" + ] + }, + "reactions": [ + { + "evidence": { + "evidenceCode": [], + "references": [ + "doi:" + ] + }, + "reactions": [ + { + "products": [ + "" + ] + } + ] + } + ] +} \ No newline at end of file From 364ddf8c38ee063b14a5e1227b189a51d388bb07 Mon Sep 17 00:00:00 2001 From: mite-bot Date: Wed, 22 Jul 2026 20:47:50 +0200 Subject: [PATCH 2/2] Update submission --- .../2bc73f10-85f9-11f1-8cab-df74baa3faa7.json | 93 +++++++++++++++++-- 1 file changed, 84 insertions(+), 9 deletions(-) diff --git a/mite_data/data/2bc73f10-85f9-11f1-8cab-df74baa3faa7.json b/mite_data/data/2bc73f10-85f9-11f1-8cab-df74baa3faa7.json index de29d207..50def244 100644 --- a/mite_data/data/2bc73f10-85f9-11f1-8cab-df74baa3faa7.json +++ b/mite_data/data/2bc73f10-85f9-11f1-8cab-df74baa3faa7.json @@ -1,6 +1,7 @@ { "accession": "MITE9999999", "status": "pending", + "comment": "L-tryptophan methyltransferase", "changelog": [ { "version": "1", @@ -16,29 +17,103 @@ ], "enzyme": { "name": "TrpM", + "description": "Methyltransferase", + "references": [ + "doi:10.1002/cbic.201800336", + "doi:10.1002/btpr.3492" + ], "databaseIds": { "uniprot": "A0A346RP51", - "genpept": "" + "genpept": "AXS67848.1" }, - "references": [ - "doi:" - ] + "cofactors": { + "organic": [ + "SAM" + ] + } }, "reactions": [ { + "tailoring": [ + "Methylation" + ], + "description": "TrpM catalyzes N-methylation of L-tryptophan to produce L-abrine (N-alpha-methyl-L-tryptophan)", + "reactionSMARTS": "[#7:1]-[#6:2](-[#6:13](-[#8:15])=[#8:14])-[#6:3]-[#6:4]1:[#6:8]2:[#6:9]:[#6:10]:[#6:11]:[#6:12]:[#6:7]:2:[#7:6]:[#6:5]:1>>[#6:2](-[#7:1]-[#6])(-[#6:13](-[#8:15])=[#8:14])-[#6:3]-[#6:4]1:[#6:8]2:[#6:9]:[#6:10]:[#6:11]:[#6:12]:[#6:7]:2:[#7:6]:[#6:5]:1", + "reactions": [ + { + "substrate": "NC(Cc1c[nH]c2ccccc12)C(=O)O", + "products": [ + "CNC(Cc1c[nH]c2ccccc12)C(=O)O" + ], + "isIntermediate": true, + "description": "TrpM methyltransferase catalyzes iterative N-methylations to produce L-abrine (N-alpha-methyl-L-tryptophan), N,N-alpha-dimethyl-L-tryptophan and L-hypaphorine (N,N,N-alpha-trimethyl-L-tryptophan). TrpM can also N-methylate the non-native amino acid substrate, 4-hydroxytryptophan." + } + ], "evidence": { - "evidenceCode": [], + "evidenceCode": [ + "In vitro assay" + ], "references": [ - "doi:" + "doi:10.1002/cbic.201800336" ] }, + "databaseIds": { + "rhea": "80771" + } + }, + { + "tailoring": [ + "Methylation" + ], + "description": "TrpM catalyzes N-methylation of L-abrine (N-alpha-methyl-L-tryptophan) to form N,N-alpha-dimethyl-L-tryptophan", + "reactionSMARTS": "[#6:1]-[#7:2]-[#6:3](-[#6:14](-[#8:16])=[#8:15])-[#6:4]-[#6:5]1:[#6:13]2:[#6:8](:[#6:9]:[#6:10]:[#6:11]:[#6:12]:2):[#7:7]:[#6:6]:1>>[#6:1]-[#7:2](-[#6])-[#6:3](-[#6:14](-[#8:16])=[#8:15])-[#6:4]-[#6:5]1:[#6:13]2:[#6:8](:[#6:9]:[#6:10]:[#6:11]:[#6:12]:2):[#7:7]:[#6:6]:1", "reactions": [ { + "substrate": "CNC(Cc1c[nH]c2ccccc12)C(=O)O", "products": [ - "" - ] + "CN(C)C(Cc1c[nH]c2ccccc12)C(=O)O" + ], + "isIntermediate": true } - ] + ], + "evidence": { + "evidenceCode": [ + "In vitro assay" + ], + "references": [ + "doi:10.1002/cbic.201800336" + ] + }, + "databaseIds": { + "rhea": "80847" + } + }, + { + "tailoring": [ + "Methylation" + ], + "description": "TrpM catalyzes N-methylation of N,N-alpha-dimethyl-L-tryptophan to yield L-hypaphorine (N,N,N-alpha-trimethyl-L-tryptophan)", + "reactionSMARTS": "[#6]-[#7](-[#6:4](-[#6:8]-[#6:9]1:[#6:17]:[#7:16]:[#6:11]2:[#6:12]:[#6:13]:[#6:14]:[#6:15]:[#6:10]:1:2)-[#6:5](=[#8:7])-[#8:6])-[#6]>>[#6]-[#7;+](-[#6])(-[#6:4](-[#6:8]-[#6:9]1:[#6:17]:[#7:16]:[#6:11]2:[#6:12]:[#6:13]:[#6:14]:[#6:15]:[#6:10]:1:2)-[#6:5](=[#8:7])-[#8:6])-[#6]", + "reactions": [ + { + "substrate": "CN(C)C(Cc1c[nH]c2ccccc12)C(=O)O", + "products": [ + "C[N+](C)(C)C(Cc1c[nH]c2ccccc12)C(=O)O" + ], + "isIntermediate": false + } + ], + "evidence": { + "evidenceCode": [ + "In vitro assay" + ], + "references": [ + "doi:10.1002/cbic.201800336" + ] + }, + "databaseIds": { + "rhea": "80851" + } } ] } \ No newline at end of file