In regards to set_ciphers method in Context class and taking into account of openssl docs - setting ciphers for TLSv1.3 (in order to achieve any effect) must be set via SSL_set_ciphersuites - elsewhere set_ciphers wont take any effect or raise exception - so that, changes require to distinguish between protocol versions - propably here: https://github.com/pyca/pyopenssl/blob/main/src/OpenSSL/SSL.py#L1327
In regards to set_ciphers method in Context class and taking into account of openssl docs - setting ciphers for TLSv1.3 (in order to achieve any effect) must be set via SSL_set_ciphersuites - elsewhere set_ciphers wont take any effect or raise exception - so that, changes require to distinguish between protocol versions - propably here: https://github.com/pyca/pyopenssl/blob/main/src/OpenSSL/SSL.py#L1327