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YAOJ-bioin/README.md
Jie Yao · 姚洁 — AI × Plant Genomics

Typing SVG


Homepage Google Scholar ORCID PEAgent Email


🧬 About · 关于我

Postdoctoral researcher in the Schmitz Lab, University of Georgia, working at the intersection of AI for Science and plant biology. I build deep-learning and epigenome-informed foundation models to decode how plant genomes encode cell-type-specific regulation. Ph.D. in Bioinformatics, Zhejiang University.

佐治亚大学 Schmitz 实验室博士后。用深度学习 × 单细胞/空间多组学,解码植物基因组的细胞类型特异性调控逻辑。浙江大学生物信息学博士。

DNA sequence → deep learning → single-cell chromatin accessibility → regulatory grammar

🤖 AI for Plant Genomics
Sequence-to-function deep learning; epigenome-informed foundation models.
面向植物基因组的序列→功能深度学习与基础模型

🔬 Single-cell & Spatial Multi-omics
scATAC / scRNA / spatial transcriptomics; computational methods & atlases.
单细胞与空间多组学:方法开发与图谱构建

🌱 Plant Epigenetics
Chromatin accessibility, cis-regulatory grammar, and its evolution across crops.
染色质可及性、顺式调控语法及其在作物间的演化

🚀 Featured Projects · 精选项目

peagent_tool
Python package for the PEAgent models — predict single-cell chromatin accessibility from DNA sequence · Docs
PEAgent 推理包:从 DNA 序列预测单细胞染色质可及性
peagent-analysis
Analysis code for the PEAgent manuscript — training, motif lexicon, synergy, cross-species, variant effects
PEAgent 论文分析代码:训练、motif 词典、协同、跨物种、变异效应
jbrowse-plugin-attrmap
JBrowse 2 plugin rendering base-resolution attribution maps (scBasset / BPNet) as sequence logos
JBrowse 2 插件:以序列 logo 形式展示碱基级模型归因图
ppEffect
R package to quantify protoplasting-induced artifacts in plant scRNA-seq
R 包:系统评估原生质体化对植物单细胞转录组的影响
REGSTA-script
Cell-wall segmentation → single-cell-resolution spatial transcriptomics for plant tissue (Stereo-seq)
植物组织细胞壁分割 → 单细胞分辨率空间转录组流程
plant-spatial-multiomics-analysis
A practical guide to plant spatial multi-omics analysis (companion to the Trends Plant Sci review) · Site
植物空间多组学分析实践指南

📝 Selected Publications · 代表论文

† co-first author · Full list on my homepage / Google Scholar

bioRxiv 2026 Yao J, Li J, Zhang X, Li X, Marand AP, Pickering E, Schmitz RJ. Sequence-based modeling of plant epigenomes reveals cell-type-specific cis-regulatory grammar. DOI · peagent.org
Trends in Plant Science 2025 Yao J, Marand AP, Bai Y, Schmitz RJ, Fan L. Advances in plant spatial multi-omics data analysis. DOI
Developmental Cell 2024 Yao J†, Chu Q†, Guo X†, Shao W†, et al., Liu H, Fan L. Spatiotemporal transcriptomic landscape of rice embryonic cells during seed germination. DOI
bioRxiv 2024 Yao J, Shang N, Chen H, et al., Chu Q. Sub-clustering, marker identification and multi-omics integration influenced by protoplasting in plant scRNA-seq data analysis. DOI
JID 2022 Zheng Y†, Yao J†, et al., Fan L. A manually curated database and analysis platform of cell markers of scars. DOI

Also contributed to: The Plant Cell 2026 · Nature Plants 2026 (scPlantReg) · Molecular Plant 2025 ×2 · Briefings in Bioinformatics 2025 · Molecular Plant 2021 (PlantscRNAdb)

🛠️ Tech Stack · 技术栈

Python TensorFlow scikit-learn R TypeScript Shell Scanpy Seurat TF--MoDISco JBrowse 2 Jupyter MkDocs Linux/HPC

📊 GitHub Stats

GitHub stats Top languages
🏅 3× National Scholarship · Outstanding Doctoral Graduate, ZJU 2025 · Reviewer for Communications Biology

Athens, GA

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  1. REGSTA-script REGSTA-script Public

    Single-cell-resolution spatial transcriptomics for plant tissue: Cellpose cell-wall segmentation → Stereo-seq cell-level matrix → Seurat (Yao et al., Dev Cell 2024)

    Python 7 2

  2. jbrowse-plugin-attrmap jbrowse-plugin-attrmap Public

    JBrowse 2 plugin for base-resolution attribution maps — render deep-learning contribution scores (scBasset / BPNet) as sequence logos in the genome browser

    TypeScript 1

  3. peagent-analysis peagent-analysis Public

    Analysis code for PEAgent — sequence-based modeling of plant epigenomes reveals cell-type-specific cis-regulatory grammar (Yao et al., 2026)

    Python 2

  4. peagent_tool peagent_tool Public

    PEAgent inference package — predict single-cell chromatin accessibility of plant genomes directly from DNA sequence (soybean, maize, rice)

    Python 2

  5. ppEffect ppEffect Public

    R package to systematically evaluate and correct protoplasting-induced effects (ppDEGs) in plant scRNA-seq data

    R 1

  6. plant-spatial-multiomics-analysis plant-spatial-multiomics-analysis Public

    A practical guide to spatial multi-omics data analysis in plants — companion site to our Trends in Plant Science review (Yao et al., 2025)