Dear Dr. Atarashansky,
I tried your wonderful tool with a dataset containing species-specific cell types, but the species-specific cell type can still map to another species' cell type with a mapping score above 0.5. Although the gene pairs supporting this only have around 100 gene pairs. If I understand your paper correctly, your method will force the species-specific cell types to map to a similar (but not homologous) cell type with much more weight on the small number of genes in the gene homology graph.
Could you confirm that?
Best wishes,
YZ
Dear Dr. Atarashansky,
I tried your wonderful tool with a dataset containing species-specific cell types, but the species-specific cell type can still map to another species' cell type with a mapping score above 0.5. Although the gene pairs supporting this only have around 100 gene pairs. If I understand your paper correctly, your method will force the species-specific cell types to map to a similar (but not homologous) cell type with much more weight on the small number of genes in the gene homology graph.
Could you confirm that?
Best wishes,
YZ