Skip to content

Contributor submission TrpM #862

New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

Sign up for GitHub

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

Open
mite-bot wants to merge 2 commits into
base: main
Choose a base branch
from
Open

Contributor submission TrpM #862

Changes from all commits
Commits
Show all changes
2 commits
Select commit Hold shift + click to select a range
fc6b5a5
Add submission UUID file
mite-bot Jul 22, 2026
364ddf8
Update submission
mite-bot Jul 22, 2026
File filter

Filter by extension

Filter by extension
Conversations
Failed to load comments.
Loading
Jump to
Jump to file
Failed to load files.
Loading
Diff view
Diff view
119 changes: 119 additions & 0 deletions mite_data/data/2bc73f10-85f9-11f1-8cab-df74baa3faa7.json
View file
Open in desktop
Original file line number Diff line number Diff line change
@@ -0,0 +1,119 @@
{
"accession": "MITE9999999",
"status": "pending",
"comment": "L-tryptophan methyltransferase",
"changelog": [
{
"version": "1",
"date": "2026-07-22",
"contributors": [
"0009-0008-8086-5325"
],
"reviewers": [
"BBBBBBBBBBBBBBBBBBBBBBBB"
],
"comment": "New entry."
}
],
"enzyme": {
"name": "TrpM",
"description": "Methyltransferase",
"references": [
"doi:10.1002/cbic.201800336",
"doi:10.1002/btpr.3492"
],
"databaseIds": {
"uniprot": "A0A346RP51",
"genpept": "AXS67848.1"
},
"cofactors": {
"organic": [
"SAM"
]
}
},
"reactions": [
{
"tailoring": [
"Methylation"
],
"description": "TrpM catalyzes N-methylation of L-tryptophan to produce L-abrine (N-alpha-methyl-L-tryptophan)",
"reactionSMARTS": "[#7:1]-[#6:2](-[#6:13](-[#8:15])=[#8:14])-[#6:3]-[#6:4]1:[#6:8]2:[#6:9]:[#6:10]:[#6:11]:[#6:12]:[#6:7]:2:[#7:6]:[#6:5]:1>>[#6:2](-[#7:1]-[#6])(-[#6:13](-[#8:15])=[#8:14])-[#6:3]-[#6:4]1:[#6:8]2:[#6:9]:[#6:10]:[#6:11]:[#6:12]:[#6:7]:2:[#7:6]:[#6:5]:1",
"reactions": [
{
"substrate": "NC(Cc1c[nH]c2ccccc12)C(=O)O",
"products": [
"CNC(Cc1c[nH]c2ccccc12)C(=O)O"
],
"isIntermediate": true,
"description": "TrpM methyltransferase catalyzes iterative N-methylations to produce L-abrine (N-alpha-methyl-L-tryptophan), N,N-alpha-dimethyl-L-tryptophan and L-hypaphorine (N,N,N-alpha-trimethyl-L-tryptophan). TrpM can also N-methylate the non-native amino acid substrate, 4-hydroxytryptophan."
}
],
"evidence": {
"evidenceCode": [
"In vitro assay"
],
"references": [
"doi:10.1002/cbic.201800336"
]
},
"databaseIds": {
"rhea": "80771"
}
},
{
"tailoring": [
"Methylation"
],
"description": "TrpM catalyzes N-methylation of L-abrine (N-alpha-methyl-L-tryptophan) to form N,N-alpha-dimethyl-L-tryptophan",
"reactionSMARTS": "[#6:1]-[#7:2]-[#6:3](-[#6:14](-[#8:16])=[#8:15])-[#6:4]-[#6:5]1:[#6:13]2:[#6:8](:[#6:9]:[#6:10]:[#6:11]:[#6:12]:2):[#7:7]:[#6:6]:1>>[#6:1]-[#7:2](-[#6])-[#6:3](-[#6:14](-[#8:16])=[#8:15])-[#6:4]-[#6:5]1:[#6:13]2:[#6:8](:[#6:9]:[#6:10]:[#6:11]:[#6:12]:2):[#7:7]:[#6:6]:1",
"reactions": [
{
"substrate": "CNC(Cc1c[nH]c2ccccc12)C(=O)O",
"products": [
"CN(C)C(Cc1c[nH]c2ccccc12)C(=O)O"
],
"isIntermediate": true
}
],
"evidence": {
"evidenceCode": [
"In vitro assay"
],
"references": [
"doi:10.1002/cbic.201800336"
]
},
"databaseIds": {
"rhea": "80847"
}
},
{
"tailoring": [
"Methylation"
],
"description": "TrpM catalyzes N-methylation of N,N-alpha-dimethyl-L-tryptophan to yield L-hypaphorine (N,N,N-alpha-trimethyl-L-tryptophan)",
"reactionSMARTS": "[#6]-[#7](-[#6:4](-[#6:8]-[#6:9]1:[#6:17]:[#7:16]:[#6:11]2:[#6:12]:[#6:13]:[#6:14]:[#6:15]:[#6:10]:1:2)-[#6:5](=[#8:7])-[#8:6])-[#6]>>[#6]-[#7;+](-[#6])(-[#6:4](-[#6:8]-[#6:9]1:[#6:17]:[#7:16]:[#6:11]2:[#6:12]:[#6:13]:[#6:14]:[#6:15]:[#6:10]:1:2)-[#6:5](=[#8:7])-[#8:6])-[#6]",
"reactions": [
{
"substrate": "CN(C)C(Cc1c[nH]c2ccccc12)C(=O)O",
"products": [
"C[N+](C)(C)C(Cc1c[nH]c2ccccc12)C(=O)O"
],
"isIntermediate": false
}
],
"evidence": {
"evidenceCode": [
"In vitro assay"
],
"references": [
"doi:10.1002/cbic.201800336"
]
},
"databaseIds": {
"rhea": "80851"
}
}
]
}
Loading