[Study]: Differences in diversity and composition of mucosa-associated colonic microbiota in colorectal cancer and non-colorectal cancer in Indonesia

[lightamadi-stack]

The Digital Object Identifier (DOI)

https://doi.org/10.3748/wjg.v31.i7.100051

Code of Conduct Agreement

• I agree to follow this project's Code of Conduct

[github-actions]

Title

Differences in diversity and composition of mucosa-associated colonic microbiota in colorectal cancer and non-colorectal cancer in Indonesia

DOI

https://doi.org/10.3748/wjg.v31.i7.100051

PMID

39991683

Author

Nikko Darnindro

Journal

World Journal of Gastroenterology

Year

2025

👋 Thanks for submitting!

[lightamadi-stack]

Hi @SvetlanaUP, kindly add the CRC label.

Thank you.

[sahilnyk]

Hello @SvetlanaUP i would like to curate this study. could you please assign it to me?

[sahilnyk]

Hello @SvetlanaUP completed curating this study and its ready for review. Thankss

https://bugsigdb.org/39991683

[lightamadi-stack]

Good day @SvetlanaUP, i would like to review this study.

Thank you.

[lightamadi-stack]

Hi @sahilnyk, great job on this curation! 👏 This is very well done.
I have a few corrections that I think will help us finalize the curation:

• Study URL: Please add the direct link to the study: https://www.wjgnet.com/1007-9327/full/v31/i7/100051.htm
• Statistical test: Please update the statistical test for both experiments to "Linear Regression or Generalized Linear Modeling (GLM)".

Experiment 1:

• For Signatures 1 and 2, let’s use the following signature description: Comparison of gut microbiota composition between colorectal cancer and non-colorectal cancer patients at the family, genus, and species levels. P values were adjusted for age and gender using a generalized linear model with gamma distribution and log link.

Experiment 2:

• For Signatures 1 and 2, let’s use the following signature description: Comparison of gut microbiota composition between colorectal cancer and non-colorectal cancer patients at the family, genus, and species levels, with unadjusted P-values.
• The sources for Signatures 1 and 2 are Tables 3, 4, and 5.
• For Signature 1, kindly add the following taxa:

1. Bacteroides (Taxon ID: 816)
2. Campylobacter (Taxon ID: 194)
3. Peptostreptococcus (Taxon ID: 1257)
4. Parvimonas (Taxon ID: 543311)
5. Bacteroides fragilis (Taxon ID: 817)
6. Fusobacterium nucleatum (Taxon ID: 851)
7. Enterococcus faecalis (Taxon ID: 1351)
8. Campylobacter hominis (Taxon ID: 76517)

• For Signature 2, kindly add the following taxa:

1. Oscillospiraceae (Taxon ID: 216572)
2. Faecalibacterium (Taxon ID: 216851)
3. Phocaeicola (Taxon ID: 909656)
4. Haemophilus (Taxon ID: 724)
5. Faecalibacterium prausnitzii (Taxon ID: 853)
6. Prevotella copri (Taxon ID: 165179)

We curate all significant taxa found for each experiment, even if some of them are also found in the other experiment. In this case, we are curating the unadjusted P-value experiment because the significant taxa are not fully overlapping between the two experiments.

Thank you!

[sahilnyk]

@lightamadi-stack Thank you for your time to review my curation, I have addressed all the fix suggested by you. Lemme know if anything else need to be corrected?

[lightamadi-stack]

Thank you so much @sahilnyk for updating the study.
@SvetlanaUP, this review is complete.