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Pfam proposals, CGD curation leads, owner decisions, per-call status spec (grilling session 2026-10-07) - #72

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pfam-proposals-and-curation-leads
Oct 8, 2026
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pfam-proposals-and-curation-leads

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What this adds

Output of the owner grilling session of 2026-10-07. Handoff: docs/HANDOFF-2026-10-07.md (decisions 1 to 12 are in section 2).

  • Pfam proposals. 122 hits in 6 proteomes, each marked proposed (docs/reports/data/sorting_hat/specificity/pfam_proposals.tsv, analysis/sorting_hat_run/pfam_proposals.py). Family-level proposal: docs/reports/2026-10-07-pfam-family-proposals.md. No family is set active. data/sorting_hat/family_table.tsv is unchanged.
  • Owner decision on Q6FTA2 and Q59TP1 (RBT1): excluded from the repeat controls only (owner_decisions.tsv, adjudication README). RBT1 keeps its adhesin E2 label with PMIDs 10978273, 19837954, 21414038. Braun 2000 was read: the two RBT1 alleles differ by a segment (aa 612 to 640), not by repeat number.
  • R0 status source added to the two S288C runs (both now smoke). Report and run copies updated.
  • FLO11 repeat miss explained (coverage 0.045 against the 0.25 cut). The FLO11 statement in analysis/cocci_repeats/REPORT_2026-09-30_pfam_confirmation.md is not supported by this measurement; that file is not changed.
  • Curation leads from CGD: docs/curation-leads/, data/curated/biofilm/cgd_biofilm_literature_leads.tsv, cgd_adherence_literature_leads.tsv.
  • Spec for per-call status entries (docs/superpowers/specs/2026-10-07-per-call-status-design.md). Draft. No independent review yet and no code.
  • Verification: YPS3 accession (name matches), BcLysM1 sentence (supported by the abstract), WHO/IUIS counts (recount of the stored table; allergen.org not queried), table B3 of docs/paper/02 (24 values match metrics.json; the B1 cell for A. nidulans is filled).

Read before merging

  • The Pfam classes are proposals from table facts, not expert reviews. 48 of 122 are needs_expert.
  • Pfam sign-off still needs: SignalP on C. neoformans H99, a C. albicans run, a decision on AltA1, an expert pass, and reviewed member lists (issue Step 2b/2c: reviewed member and non-member controls and specificity tests for the 15 Pfam families (task 04) #69). None of these runs was done here.
  • Not verified: the three cell wall reviews, the other "copied" rows of docs/paper/02.
  • The STAR job of 2026-10-03 failed (BAM sorting memory); the handoff says so. It was not rerun.

Pre-commit (ruff 0.3.5 and ruff-format) passes. pfam_proposals.py reproduces the stored TSV exactly. No test was added: the scripts are analysis scripts.

🤖 Generated with Claude Code

hyphaltip and others added 3 commits October 7, 2026 16:38
…all status spec, verification, handoff

- Pfam proposals for 122 hits in 6 proteomes (status proposed; no family set active)
- CGD biofilm and cell wall literature leads; RBT1 evidence; owner_decisions.tsv for Q6FTA2 and Q59TP1
- R0 status source added to the two S288C runs; FLO11 repeat miss explained
- Spec for per-call status entries (draft, not reviewed)
- Verification of YPS3, BcLysM1, WHO/IUIS counts and table B3
- Handoff of 2026-10-07

Co-Authored-By: Claude Sonnet 5.5 <noreply@anthropic.com>
Claude-Session: https://claude.ai/code/session_01JXibAde2qW2uRZ4pShs1sW
Review (Opus, read-only): needs rework. Two blockers and eight majors applied; owner questions Q6 to Q8 marked.

Co-Authored-By: Claude Sonnet 5.5 <noreply@anthropic.com>
Claude-Session: https://claude.ai/code/session_01JXibAde2qW2uRZ4pShs1sW
…roposals for 159 hits in 8 proteomes

The Phase C C. albicans FASTA has 38 duplicate IDs with identical sequences; a deduplicated copy was used.
HWP1, HWP2 and EAP1 have no hit from any of the 15 models.

Co-Authored-By: Claude Sonnet 5.5 <noreply@anthropic.com>
Claude-Session: https://claude.ai/code/session_01JXibAde2qW2uRZ4pShs1sW
@hyphaltip
hyphaltip merged commit 6133ba9 into main Oct 8, 2026
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hyphaltip deleted the pfam-proposals-and-curation-leads branch October 8, 2026 03:33
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